Drug Repurposing as an Antitumor Agent: Disulfiram-Mediated Carbonic Anhydrase 12 and Anion Exchanger 2 Modulation to Inhibit Cancer Cell Migration

Disulfiram has been used in the treatment of alcoholism and exhibits an anti-tumor effect.However, the intracellular mechanism of anti-tumor activity of diegojavierfares.com Disulfiram remains unclear.In this study, we focused on the modulatory role of Disulfiram via oncogenic factor carbonic anhydrase CA12 and its associated transporter anion exch

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Early and noninvasive diagnosis using serological antigen biomarkers in chronic invasive fungal rhinosinusitis

Background: Chronic invasive form of fungal rhinosinusitis (FRS) is characterized by the invasion of fungal organisms into the sinonasal mucosa in the background of diabetes mellitus and corticosteroid treatment.Although the histopathology has traditionally been used to make a proven diagnosis of invasive fungal infections, the dependence on tissue

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